Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

T cell development requires phosphatidylinositol 3-kinase (PI3K) signaling with contributions from both the class IA, p110δ, and class IB, p110γ catalytic subunits. However, the receptors on immature T cells by which each of these PI3Ks are activated have not been identified, nor has the mechanism b...

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Detalles Bibliográficos
Autores principales: Janas, Michelle L., Varano, Gabriele, Gudmundsson, Kristjan, Noda, Mamiko, Nagasawa, Takashi, Turner, Martin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812547/
https://www.ncbi.nlm.nih.gov/pubmed/20038597
http://dx.doi.org/10.1084/jem.20091430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812547/
https://www.ncbi.nlm.nih.gov/pubmed/20038597
http://dx.doi.org/10.1084/jem.20091430

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