Notch3 Cooperates With the EGFR Pathway to Modulate Apoptosis Through The Induction Of Bim

Notch signaling is a highly conserved pathway important for normal embryonic development and as well as cancer. We previously demonstrated a role for Notch3 in lung cancer pathogenesis. Notch3 inhibition resulted in tumor apoptosis and growth suppression. In vitro, these effects were enhanced when t...

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Detalles Bibliográficos
Autores principales: Konishi, Jun, Yi, Fuming, Chen, Xinping, Vo, Huan, Carbone, David P., Dang, Thao P.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813325/
https://www.ncbi.nlm.nih.gov/pubmed/19881544
http://dx.doi.org/10.1038/onc.2009.366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813325/
https://www.ncbi.nlm.nih.gov/pubmed/19881544
http://dx.doi.org/10.1038/onc.2009.366

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