The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies

BACKGROUND: In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solution has been described. This would diminish plasma levels in chronic minipump studies a...

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Detalles Bibliográficos
Autores principales: Vinkers, Christiaan H., Korte-Bouws, Gerdien A. H., Sastre Toraño, Javier, Mirza, Naheed R., Nielsen, Elsebet Ø., Ahring, Philip K., de Jong, Gerhardus J., Olivier, Berend
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813522/
https://www.ncbi.nlm.nih.gov/pubmed/20066402
http://dx.doi.org/10.1007/s00213-009-1752-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813522/
https://www.ncbi.nlm.nih.gov/pubmed/20066402
http://dx.doi.org/10.1007/s00213-009-1752-8

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