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Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.

Detalles Bibliográficos
Autores principales: Rolland, Julien, Cambeiro, Xacobe C, Rodríguez-Escrich, Carles, Pericàs, Miquel A
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813714/
https://www.ncbi.nlm.nih.gov/pubmed/20126636
http://dx.doi.org/10.3762/bjoc.5.56