Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.

Detalles Bibliográficos
Autores principales: Rolland, Julien, Cambeiro, Xacobe C, Rodríguez-Escrich, Carles, Pericàs, Miquel A
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813714/
https://www.ncbi.nlm.nih.gov/pubmed/20126636
http://dx.doi.org/10.3762/bjoc.5.56
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author Rolland, Julien
Cambeiro, Xacobe C
Rodríguez-Escrich, Carles
Pericàs, Miquel A
author_facet Rolland, Julien
Cambeiro, Xacobe C
Rodríguez-Escrich, Carles
Pericàs, Miquel A
author_sort Rolland, Julien
collection PubMed
description A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.
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spelling pubmed-28137142010-02-01 Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups Rolland, Julien Cambeiro, Xacobe C Rodríguez-Escrich, Carles Pericàs, Miquel A Beilstein J Org Chem Full Research Paper A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc. Beilstein-Institut 2009-10-15 /pmc/articles/PMC2813714/ /pubmed/20126636 http://dx.doi.org/10.3762/bjoc.5.56 Text en Copyright © 2009, Rolland et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Rolland, Julien
Cambeiro, Xacobe C
Rodríguez-Escrich, Carles
Pericàs, Miquel A
Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
title Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
title_full Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
title_fullStr Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
title_full_unstemmed Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
title_short Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
title_sort continuous flow enantioselective arylation of aldehydes with arznet using triarylboroxins as the ultimate source of aryl groups
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813714/
https://www.ncbi.nlm.nih.gov/pubmed/20126636
http://dx.doi.org/10.3762/bjoc.5.56
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