Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectabl...

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Autores principales: Beloueche-Babari, M, Chung, Y-L, Al-Saffar, N M S, Falck-Miniotis, M, Leach, M O
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813738/
https://www.ncbi.nlm.nih.gov/pubmed/19935796
http://dx.doi.org/10.1038/sj.bjc.6605457
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author Beloueche-Babari, M
Chung, Y-L
Al-Saffar, N M S
Falck-Miniotis, M
Leach, M O
author_facet Beloueche-Babari, M
Chung, Y-L
Al-Saffar, N M S
Falck-Miniotis, M
Leach, M O
author_sort Beloueche-Babari, M
collection PubMed
description Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use.
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spelling pubmed-28137382011-01-05 Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy Beloueche-Babari, M Chung, Y-L Al-Saffar, N M S Falck-Miniotis, M Leach, M O Br J Cancer Minireview Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use. Nature Publishing Group 2010-01-05 2009-11-24 /pmc/articles/PMC2813738/ /pubmed/19935796 http://dx.doi.org/10.1038/sj.bjc.6605457 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Beloueche-Babari, M
Chung, Y-L
Al-Saffar, N M S
Falck-Miniotis, M
Leach, M O
Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
title Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
title_full Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
title_fullStr Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
title_full_unstemmed Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
title_short Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
title_sort metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813738/
https://www.ncbi.nlm.nih.gov/pubmed/19935796
http://dx.doi.org/10.1038/sj.bjc.6605457
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