A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

BACKGROUND: Owing to its role in cancer, the phosphoinositide 3-kinase (PI3K)/Akt pathway is an attractive target for therapeutic intervention. We previously reported that the inhibition of Akt by inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) results in anti-tumour properties. To further develop th...

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Detalles Bibliográficos
Autores principales: Falasca, M, Chiozzotto, D, Godage, H Y, Mazzoletti, M, Riley, A M, Previdi, S, Potter, B V L, Broggini, M, Maffucci, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813745/
https://www.ncbi.nlm.nih.gov/pubmed/20051961
http://dx.doi.org/10.1038/sj.bjc.6605408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813745/
https://www.ncbi.nlm.nih.gov/pubmed/20051961
http://dx.doi.org/10.1038/sj.bjc.6605408

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