Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native I (Kr) and Modulates Cardiac Action Potential Characteristics

BACKGROUND: The repolarizing cardiac rapid delayed rectifier current, I (Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I (Kr). Marked heterogeneity in the kinetic properties of native I (Kr) has been described. We...

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Detalles Bibliográficos
Autores principales: Larsen, Anders Peter, Olesen, Søren-Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814852/
https://www.ncbi.nlm.nih.gov/pubmed/20126398
http://dx.doi.org/10.1371/journal.pone.0009021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814852/
https://www.ncbi.nlm.nih.gov/pubmed/20126398
http://dx.doi.org/10.1371/journal.pone.0009021

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