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Differential Expression of hERG1 Channel Isoforms Reproduces Properties of Native I (Kr) and Modulates Cardiac Action Potential Characteristics
BACKGROUND: The repolarizing cardiac rapid delayed rectifier current, I (Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I (Kr). Marked heterogeneity in the kinetic properties of native I (Kr) has been described. We...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814852/ https://www.ncbi.nlm.nih.gov/pubmed/20126398 http://dx.doi.org/10.1371/journal.pone.0009021 |