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Optimization of minimum set of protein–DNA interactions: a quasi exact solution with minimum over-fitting
Motivation: A major limitation in modeling protein interactions is the difficulty of assessing the over-fitting of the training set. Recently, an experimentally based approach that integrates crystallographic information of C2H2 zinc finger–DNA complexes with binding data from 11 mutants, 7 from EGR...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815656/ https://www.ncbi.nlm.nih.gov/pubmed/19965883 http://dx.doi.org/10.1093/bioinformatics/btp664 |