Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE)
Deposition and mobilization of fat in an organism are tightly controlled by multiple levels of endocrine and neuroendocrine regulation. Because these hormonal mechanisms ultimately act by affecting biochemical reactions of fat synthesis or utilization, obesity could be also modulated by altering dir...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815766/ https://www.ncbi.nlm.nih.gov/pubmed/20157589 |
_version_ | 1782177041583439872 |
---|---|
author | Singh, Sharda P. Niemczyk, Maciej Zimniak, Ludwika Zimniak, Piotr |
author_facet | Singh, Sharda P. Niemczyk, Maciej Zimniak, Ludwika Zimniak, Piotr |
author_sort | Singh, Sharda P. |
collection | PubMed |
description | Deposition and mobilization of fat in an organism are tightly controlled by multiple levels of endocrine and neuroendocrine regulation. Because these hormonal mechanisms ultimately act by affecting biochemical reactions of fat synthesis or utilization, obesity could be also modulated by altering directly the underlying lipid biochemistry. We have previously shown that genetically modified mice with an elevated level of the lipid peroxidation product 4-HNE become obese. We now demonstrate that the process is phylogenetically conserved and thus likely to be universal. In the nematode C. elegans, disruption of either conjugation or oxidation of 4-HNE leads to fat accumulation, whereas augmentation of 4-HNE conjugation results in a lean phenotype. Moreover, direct treatment of C. elegans with synthetic 4-HNE causes increased lipid storage, directly demonstrating a causative role of 4-HNE. The postulated mechanism, which involves modulation of acetyl-CoA carboxylase activity, could contribute to the triggering and maintenance of the obese phenotype on a purely metabolic level. |
format | Text |
id | pubmed-2815766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-28157662010-02-12 Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) Singh, Sharda P. Niemczyk, Maciej Zimniak, Ludwika Zimniak, Piotr Aging (Albany NY) Research Article Deposition and mobilization of fat in an organism are tightly controlled by multiple levels of endocrine and neuroendocrine regulation. Because these hormonal mechanisms ultimately act by affecting biochemical reactions of fat synthesis or utilization, obesity could be also modulated by altering directly the underlying lipid biochemistry. We have previously shown that genetically modified mice with an elevated level of the lipid peroxidation product 4-HNE become obese. We now demonstrate that the process is phylogenetically conserved and thus likely to be universal. In the nematode C. elegans, disruption of either conjugation or oxidation of 4-HNE leads to fat accumulation, whereas augmentation of 4-HNE conjugation results in a lean phenotype. Moreover, direct treatment of C. elegans with synthetic 4-HNE causes increased lipid storage, directly demonstrating a causative role of 4-HNE. The postulated mechanism, which involves modulation of acetyl-CoA carboxylase activity, could contribute to the triggering and maintenance of the obese phenotype on a purely metabolic level. Impact Journals LLC 2008-12-18 /pmc/articles/PMC2815766/ /pubmed/20157589 Text en Copyright: ©2009 Singh et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Singh, Sharda P. Niemczyk, Maciej Zimniak, Ludwika Zimniak, Piotr Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) |
title | Fat accumulation in Caenorhabditis elegans triggered
by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) |
title_full | Fat accumulation in Caenorhabditis elegans triggered
by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) |
title_fullStr | Fat accumulation in Caenorhabditis elegans triggered
by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) |
title_full_unstemmed | Fat accumulation in Caenorhabditis elegans triggered
by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) |
title_short | Fat accumulation in Caenorhabditis elegans triggered
by the electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE) |
title_sort | fat accumulation in caenorhabditis elegans triggered
by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-hne) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815766/ https://www.ncbi.nlm.nih.gov/pubmed/20157589 |
work_keys_str_mv | AT singhshardap fataccumulationincaenorhabditiseleganstriggeredbytheelectrophiliclipidperoxidationproduct4hydroxynonenal4hne AT niemczykmaciej fataccumulationincaenorhabditiseleganstriggeredbytheelectrophiliclipidperoxidationproduct4hydroxynonenal4hne AT zimniakludwika fataccumulationincaenorhabditiseleganstriggeredbytheelectrophiliclipidperoxidationproduct4hydroxynonenal4hne AT zimniakpiotr fataccumulationincaenorhabditiseleganstriggeredbytheelectrophiliclipidperoxidationproduct4hydroxynonenal4hne |