Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

Aberrant signaling causes many diseases, and manipulating signaling pathways with kinase inhibitors has emerged as a promising area of drug research. Most kinase inhibitors target the conserved ATP-binding pocket; therefore specificity is a major concern. Proteomics has previously been used to ident...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Cuiping, Olsen, Jesper V., Daub, Henrik, Mann, Matthias
Formato: Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816010/
https://www.ncbi.nlm.nih.gov/pubmed/19651622
http://dx.doi.org/10.1074/mcp.M900285-MCP200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816010/
https://www.ncbi.nlm.nih.gov/pubmed/19651622
http://dx.doi.org/10.1074/mcp.M900285-MCP200

Ejemplares similares