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Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics
Aberrant signaling causes many diseases, and manipulating signaling pathways with kinase inhibitors has emerged as a promising area of drug research. Most kinase inhibitors target the conserved ATP-binding pocket; therefore specificity is a major concern. Proteomics has previously been used to ident...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816010/ https://www.ncbi.nlm.nih.gov/pubmed/19651622 http://dx.doi.org/10.1074/mcp.M900285-MCP200 |