Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype

Hsp90 is an ATP-dependent molecular chaperone that regulates key signaling proteins and thereby impacts cell growth and development. Chaperone cycle of Hsp90 is regulated by ATP binding and hydrolysis through its intrinsic ATPase activities, which is in turn modulated by interaction with its co-chap...

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Detalles Bibliográficos
Autores principales: Vali, Shireen, Pallavi, Rani, Kapoor, Shweta, Tatu, Utpal
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816227/
https://www.ncbi.nlm.nih.gov/pubmed/19856130
http://dx.doi.org/10.1007/s11693-009-9046-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816227/
https://www.ncbi.nlm.nih.gov/pubmed/19856130
http://dx.doi.org/10.1007/s11693-009-9046-3

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