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Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype
Hsp90 is an ATP-dependent molecular chaperone that regulates key signaling proteins and thereby impacts cell growth and development. Chaperone cycle of Hsp90 is regulated by ATP binding and hydrolysis through its intrinsic ATPase activities, which is in turn modulated by interaction with its co-chap...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816227/ https://www.ncbi.nlm.nih.gov/pubmed/19856130 http://dx.doi.org/10.1007/s11693-009-9046-3 |