A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication

We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype C...

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Detalles Bibliográficos
Autores principales: Lee, Soo-Youn, Ki, Chang-Seok, Hong, Kyung Sue, Kim, Jong Won
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2004
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816343/
https://www.ncbi.nlm.nih.gov/pubmed/15483356
http://dx.doi.org/10.3346/jkms.2004.19.5.750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816343/
https://www.ncbi.nlm.nih.gov/pubmed/15483356
http://dx.doi.org/10.3346/jkms.2004.19.5.750

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