A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication

We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype C...

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Detalles Bibliográficos
Autores principales: Lee, Soo-Youn, Ki, Chang-Seok, Hong, Kyung Sue, Kim, Jong Won
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2004
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816343/
https://www.ncbi.nlm.nih.gov/pubmed/15483356
http://dx.doi.org/10.3346/jkms.2004.19.5.750
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author Lee, Soo-Youn
Ki, Chang-Seok
Hong, Kyung Sue
Kim, Jong Won
author_facet Lee, Soo-Youn
Ki, Chang-Seok
Hong, Kyung Sue
Kim, Jong Won
author_sort Lee, Soo-Youn
collection PubMed
description We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B. This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.
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spelling pubmed-28163432010-02-04 A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication Lee, Soo-Youn Ki, Chang-Seok Hong, Kyung Sue Kim, Jong Won J Korean Med Sci Case Report We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B. This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT. The Korean Academy of Medical Sciences 2004-10 2004-10-30 /pmc/articles/PMC2816343/ /pubmed/15483356 http://dx.doi.org/10.3346/jkms.2004.19.5.750 Text en Copyright © 2004 The Korean Academy of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Soo-Youn
Ki, Chang-Seok
Hong, Kyung Sue
Kim, Jong Won
A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
title A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
title_full A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
title_fullStr A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
title_full_unstemmed A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
title_short A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
title_sort case report of a poor metabolizer of cyp2d6 presented with unusual responses to nortriptyline medication
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816343/
https://www.ncbi.nlm.nih.gov/pubmed/15483356
http://dx.doi.org/10.3346/jkms.2004.19.5.750
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