Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Mitochondrial DNA (mtDNA) mutations are a cause of human disease and are proposed to have a role in human aging. Clonally expanded mtDNA point mutations have been detected in replicating tissues and have been shown to cause respiratory chain (RC) defects. The effect of these mutations on other cellu...

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Detalles Bibliográficos
Autores principales: Nooteboom, Marco, Johnson, Riem, Taylor, Robert W, Wright, Nicholas A, Lightowlers, Robert N, Kirkwood, Thomas B L, Mathers, John C, Turnbull, Doug M, Greaves, Laura C
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Short Takes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816353/
https://www.ncbi.nlm.nih.gov/pubmed/19878146
http://dx.doi.org/10.1111/j.1474-9726.2009.00531.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816353/
https://www.ncbi.nlm.nih.gov/pubmed/19878146
http://dx.doi.org/10.1111/j.1474-9726.2009.00531.x

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