A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion

BACKGROUND: Carcinoma-associated fibroblasts (CAFs) can promote the progression of tumours in many ways. They can remodel the extracellular matrix to generate an environment that enables the invasion of cancer cells. We hypothesised that compounds that prevent matrix remodelling by CAFs would block...

Descripción completa

Detalles Bibliográficos
Autores principales: Hooper, S, Gaggioli, C, Sahai, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816649/
https://www.ncbi.nlm.nih.gov/pubmed/19953096
http://dx.doi.org/10.1038/sj.bjc.6605469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816649/
https://www.ncbi.nlm.nih.gov/pubmed/19953096
http://dx.doi.org/10.1038/sj.bjc.6605469

Ejemplares similares