Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is associated with decreased adhesion and acquisition of metastatic potential of breast cancer cells. Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the...

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Detalles Bibliográficos
Autores principales: Chen, J, Imanaka, N, Griffin, J D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816657/
https://www.ncbi.nlm.nih.gov/pubmed/20010940
http://dx.doi.org/10.1038/sj.bjc.6605486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816657/
https://www.ncbi.nlm.nih.gov/pubmed/20010940
http://dx.doi.org/10.1038/sj.bjc.6605486

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