Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

Expansion of a stretch of polyglutamine in huntingtin (htt), the protein product of the IT15 gene, causes Huntington's disease (HD). Previous investigations into the role of the polyglutamine stretch (polyQ) in htt function have suggested that its length may modulate a normal htt function invol...

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Detalles Bibliográficos
Autores principales: Zheng, Shuqiu, Clabough, Erin B. D., Sarkar, Sovan, Futter, Marie, Rubinsztein, David C., Zeitlin, Scott O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816686/
https://www.ncbi.nlm.nih.gov/pubmed/20140187
http://dx.doi.org/10.1371/journal.pgen.1000838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816686/
https://www.ncbi.nlm.nih.gov/pubmed/20140187
http://dx.doi.org/10.1371/journal.pgen.1000838

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