Cargando…

The Overlap of Small Molecule and Protein Binding Sites within Families of Protein Structures

Protein–protein interactions are challenging targets for modulation by small molecules. Here, we propose an approach that harnesses the increasing structural coverage of protein complexes to identify small molecules that may target protein interactions. Specifically, we identify ligand and protein b...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Fred P., Sali, Andrej
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816688/
https://www.ncbi.nlm.nih.gov/pubmed/20140189
http://dx.doi.org/10.1371/journal.pcbi.1000668