Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

BACKGROUND: Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, making...

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Detalles Bibliográficos
Autores principales: Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E., Arnold, Beth A., Toner, Timothy J., Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T., Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frederic, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R., Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N., Franlin, Laura L., Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J., Audoly, Laurent P., Aster, Jon C., Blacklow, Stephen C., Huber, Hans E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817004/
https://www.ncbi.nlm.nih.gov/pubmed/20161710
http://dx.doi.org/10.1371/journal.pone.0009094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817004/
https://www.ncbi.nlm.nih.gov/pubmed/20161710
http://dx.doi.org/10.1371/journal.pone.0009094

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