DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

BACKGROUND: Thymic epithelial cell (TEC) microenvironments are essential for the recruitment of T cell precursors from the bone marrow, as well as the subsequent expansion and selection of thymocytes resulting in a mature self-tolerant T cell repertoire. The molecular mechanisms, which control both...

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Detalles Bibliográficos
Autores principales: Osada, Masako, Jardine, Logan, Misir, Ruth, Andl, Thomas, Millar, Sarah E., Pezzano, Mark
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817005/
https://www.ncbi.nlm.nih.gov/pubmed/20161711
http://dx.doi.org/10.1371/journal.pone.0009062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817005/
https://www.ncbi.nlm.nih.gov/pubmed/20161711
http://dx.doi.org/10.1371/journal.pone.0009062

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