Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms

p53 maintains genome integrity by initiating the transcription of genes involved in cell-cycle arrest, senescence, apoptosis and DNA repair. The activity of p53 is regulated by both post-translational modifications and protein–protein interactions. p53 that has been phosphorylated at S366, S378 and...

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Detalles Bibliográficos
Autores principales: Rajagopalan, Sridharan, Sade, Robert S., Townsley, Fiona M., Fersht, Alan R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817464/
https://www.ncbi.nlm.nih.gov/pubmed/19933256
http://dx.doi.org/10.1093/nar/gkp1041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817464/
https://www.ncbi.nlm.nih.gov/pubmed/19933256
http://dx.doi.org/10.1093/nar/gkp1041

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