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Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides
Oxidized DNA precursors can cause mutagenesis and carcinogenesis when they are incorporated into the genome. Some human Y-family DNA polymerases (Pols) can effectively incorporate 8-oxo-dGTP, an oxidized form of dGTP, into a position opposite a template dA. This inappropriate G:A pairing may lead to...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817480/ https://www.ncbi.nlm.nih.gov/pubmed/19939936 http://dx.doi.org/10.1093/nar/gkp1095 |