Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

Genes mutated in congenital malformation syndromes are frequently implicated in oncogenesis1,2, but the causative germline and somatic mutations occur in separate cells at different times of an organism’s life. Here we unify these processes for mutations arising in male germ cells that show a patern...

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Detalles Bibliográficos
Autores principales: Goriely, Anne, Hansen, Ruth M. S., Taylor, Indira B., Olesen, Inge A., Jacobsen, Grete Krag, McGowan, Simon J., Pfeifer, Susanne P., McVean, Gilean A. T., Meyts, Ewa Rajpert-De, Wilkie, Andrew O.M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817493/
https://www.ncbi.nlm.nih.gov/pubmed/19855393
http://dx.doi.org/10.1038/ng.470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817493/
https://www.ncbi.nlm.nih.gov/pubmed/19855393
http://dx.doi.org/10.1038/ng.470

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