Hydrogen Bonding Progressively Strengthens upon Transfer of the Protein Urea-Denatured State to Water and Protecting Osmolytes

[Image: see text] Using osmolyte cosolvents, we show that hydrogen-bonding contributions can be separated from hydrophobic interactions in the denatured state ensemble (DSE). Specifically, the effects of urea and the protecting osmolytes sarcosine and TMAO are reported on the thermally unfolded DSE...

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Detalles Bibliográficos
Autores principales: Holthauzen, Luis Marcelo F., Rösgen, Jörg, Bolen, D. Wayne
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817916/
https://www.ncbi.nlm.nih.gov/pubmed/20073511
http://dx.doi.org/10.1021/bi9015499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817916/
https://www.ncbi.nlm.nih.gov/pubmed/20073511
http://dx.doi.org/10.1021/bi9015499

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