Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers

The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine and rimantadine 1. Resistance to these drugs has compromised their effectiveness against many influenza strains, including pandemic H1N1. A recent crystal structure of M2(2...

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Detalles Bibliográficos
Autores principales: Cady, Sarah D., Schmidt-Rohr, Klaus, Wang, Jun, Soto, Cinque S., DeGrado, William F., Hong, Mei
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818718/
https://www.ncbi.nlm.nih.gov/pubmed/20130653
http://dx.doi.org/10.1038/nature08722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818718/
https://www.ncbi.nlm.nih.gov/pubmed/20130653
http://dx.doi.org/10.1038/nature08722

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