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Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers
The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine and rimantadine 1. Resistance to these drugs has compromised their effectiveness against many influenza strains, including pandemic H1N1. A recent crystal structure of M2(2...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818718/ https://www.ncbi.nlm.nih.gov/pubmed/20130653 http://dx.doi.org/10.1038/nature08722 |