Cargando…

Complement Component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort

PURPOSE: A non-synonymous single nucleotide polymorphism (SNP) in complement component 3 has been shown to increase the risk of age-related macular degeneration (AMD). We assess its effect on AMD risk in a Northern Irish sample, test for gene–gene and gene–environment interaction, and review a risk...

Descripción completa

Detalles Bibliográficos
Autores principales:	McKay, Gareth J., Dasari, Shilpa, Patterson, Christopher C., Chakravarthy, Usha, Silvestri, Giuliana
Formato:	Texto
Lenguaje:	English
Publicado:	Molecular Vision 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820106/ https://www.ncbi.nlm.nih.gov/pubmed/20157618

Ejemplares similares

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD
por: Lechner, Judith, et al.
Publicado: (2016)

Evaluation of the Retinal Vasculature in Hypertension and Chronic Kidney Disease in an Elderly Population of Irish Nuns
por: McGowan, Amy, et al.
Publicado: (2015)

A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)
por: Grassmann, Felix, et al.
Publicado: (2015)

Dietary patterns and chronic kidney disease: a cross-sectional association in the Irish Nun Eye Study
por: Paterson, Euan N., et al.
Publicado: (2018)

Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis
por: Du, Hongjun, et al.
Publicado: (2016)

Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)
por: Grassmann, Felix, et al.
Publicado: (2016)

Variability of the Transferrin Receptor 2 Gene in AMD
por: Wysokinski, Daniel, et al.
Publicado: (2014)

Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population
por: Meng, Weihua, et al.
Publicado: (2007)

AMD and the alternative complement pathway: genetics and functional implications
por: Tan, Perciliz L., et al.
Publicado: (2016)

Complement Activation Levels Are Related to Disease Stage in AMD
por: Heesterbeek, Thomas J., et al.
Publicado: (2020)

Systems Biology Profiling of AMD on the Basis of Gene Expression
por: Abu-Asab, Mones S., et al.
Publicado: (2013)

DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways
por: SanGiovanni, John Paul, et al.
Publicado: (2013)

Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids
por: Nashine, Sonali, et al.
Publicado: (2016)

The complement system: a gateway to gene-environment interactions in schizophrenia pathogenesis
por: Nimgaonkar, Vishwajit L., et al.
Publicado: (2017)

Dietary Patterns and Retinal Vessel Caliber in the Irish Nun Eye Study
por: Neville, Charlotte E., et al.
Publicado: (2017)

Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD
por: Biswal, Manas R., et al.
Publicado: (2017)

MOBILIZATION STUDIES IN COMPLEMENT-DEFICIENT MICE REVEAL THAT OPTIMAL AMD3100 MOBILIZATION OF HEMATOPOIETIC STEM CELLS DEPENDS ON COMPLEMENT CASCADE ACTIVATION BY AMD3100-STIMULATED GRANULOCYTES
por: Lee, HakMo, et al.
Publicado: (2009)

Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B
por: Pilotti, Camilla, et al.
Publicado: (2020)

Association Analysis of Dyslipidemia-Related Genes in Diabetic Nephropathy
por: McKay, Gareth J., et al.
Publicado: (2013)

Association Study of the Complement Component C4 Gene in Tardive Dyskinesia
por: Zai, Clement C., et al.
Publicado: (2019)

Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue
por: Kawa, Milosz P., et al.
Publicado: (2014)

Impact of macular fluid volume fluctuations on visual acuity during anti-VEGF therapy in eyes with nAMD
por: Chakravarthy, Usha, et al.
Publicado: (2021)

Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis
por: Yu, Qianqian, et al.
Publicado: (2020)

Root Pulling Force Across Drought in Maize Reveals Genotype by Environment Interactions and Candidate Genes
por: Woods, Patrick, et al.
Publicado: (2022)

Neovascular Age-Related Macular Degeneration Risk Based on CFH, LOC387715/HTRA1, and Smoking
por: Hughes, Anne E, et al.
Publicado: (2007)

DNA Damage/Repair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients
por: Wozniak, Katarzyna, et al.
Publicado: (2009)

RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models
por: Millington-Ward, Sophia, et al.
Publicado: (2023)

Human genes for three complement components that regulate the activation of C3 are tightly linked
Publicado: (1985)

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2
por: Pinelli, Michele, et al.
Publicado: (2012)

Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine
por: Maugeri, Andrea, et al.
Publicado: (2018)

HisCoM-G×E: Hierarchical Structural Component Analysis of Gene-Based Gene–Environment Interactions
por: Choi, Sungkyoung, et al.
Publicado: (2020)

Gene × gene and gene × environment interactions for complex disorders
por: Culverhouse, Robert, et al.
Publicado: (2007)

Association between Variant Y402H in Age-Related Macular Degeneration (AMD) Susceptibility Gene CFH and Treatment Response of AMD: A Meta-Analysis
por: Chen, Han, et al.
Publicado: (2012)

Variance-component-based meta-analysis of gene–environment interactions for rare variants
por: Jin, Xiaoqin, et al.
Publicado: (2021)

It's Not the Genes OR the Environment, It's the Genes AND the Environment!
por: Williams, Redford B.
Publicado: (2021)

Gene-Environment Dependence Creates Spurious Gene-Environment Interaction
por: Dudbridge, Frank, et al.
Publicado: (2014)

Autism risk factors: genes, environment, and gene-environment interactions
por: Chaste, Pauline, et al.
Publicado: (2012)

Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population
por: Buentello-Volante, Beatriz, et al.
Publicado: (2012)

A Cross-Sectional Study of Myopia and Morning Melatonin Status in Northern Irish Adolescent Children
por: Fulton, Jane M., et al.
Publicado: (2023)

Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD
por: Reid, Christopher A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3866pohhta91r4i184vjabmcpr