Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 and PC7. The binding pockets of all seven propr...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Sun, Jianhua, Wu
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820236/
https://www.ncbi.nlm.nih.gov/pubmed/20151049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820236/
https://www.ncbi.nlm.nih.gov/pubmed/20151049

Ejemplares similares