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Structural and Functional Restraints on the Occurrence of Single Amino Acid Variations in Human Proteins
Human genetic variation is the incarnation of diverse evolutionary history, which reflects both selectively advantageous and selectively neutral change. In this study, we catalogue structural and functional features of proteins that restrain genetic variation leading to single amino acid substitutio...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820541/ https://www.ncbi.nlm.nih.gov/pubmed/20169194 http://dx.doi.org/10.1371/journal.pone.0009186 |