Mechanistic Characterization and Molecular Modeling of Hepatitis B Virus Polymerase Resistance to Entecavir

BACKGROUND: Entecavir (ETV) is a deoxyguanosine analog competitive inhibitor of hepatitis B virus (HBV) polymerase that exhibits delayed chain termination of HBV DNA. A high barrier to entecavir-resistance (ETVr) is observed clinically, likely due to its potency and a requirement for multiple resist...

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Detalles Bibliográficos
Autores principales: Walsh, Ann W., Langley, David R., Colonno, Richard J., Tenney, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820545/
https://www.ncbi.nlm.nih.gov/pubmed/20169198
http://dx.doi.org/10.1371/journal.pone.0009195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820545/
https://www.ncbi.nlm.nih.gov/pubmed/20169198
http://dx.doi.org/10.1371/journal.pone.0009195

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