Mechanism of attenuation of leptin signaling under chronic ligand stimulation

BACKGROUND: Leptin is an adipocyte-derived hormone that acts via its hypothalamic receptor (LEPRb) to regulate energy balance. A downstream effect essential for the weight-regulatory action of leptin is the phosphorylation and activation of the latent transcription factor STAT3 by LEPRb-associated J...

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Detalles Bibliográficos
Autores principales: Knobelspies, Holger, Zeidler, Julia, Hekerman, Paul, Bamberg-Lemper, Simone, Becker, Walter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821298/
https://www.ncbi.nlm.nih.gov/pubmed/20059770
http://dx.doi.org/10.1186/1471-2091-11-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821298/
https://www.ncbi.nlm.nih.gov/pubmed/20059770
http://dx.doi.org/10.1186/1471-2091-11-2

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