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Mechanism of attenuation of leptin signaling under chronic ligand stimulation
BACKGROUND: Leptin is an adipocyte-derived hormone that acts via its hypothalamic receptor (LEPRb) to regulate energy balance. A downstream effect essential for the weight-regulatory action of leptin is the phosphorylation and activation of the latent transcription factor STAT3 by LEPRb-associated J...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821298/ https://www.ncbi.nlm.nih.gov/pubmed/20059770 http://dx.doi.org/10.1186/1471-2091-11-2 |