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SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model organisms, and has also been linked to the in...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821410/ https://www.ncbi.nlm.nih.gov/pubmed/20169165 http://dx.doi.org/10.1371/journal.pone.0009199 |