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SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent deacetylase that is known to regulate caloric restriction mediated longevity in model organisms, and has also been linked to the in...

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Detalles Bibliográficos
Autores principales:	Ghosh, Hiyaa Singhee, McBurney, Michael, Robbins, Paul D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821410/ https://www.ncbi.nlm.nih.gov/pubmed/20169165 http://dx.doi.org/10.1371/journal.pone.0009199

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