Chemical Phylogenetics of Histone Deacetylases

The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of Class I and II HDACs as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even amo...

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Detalles Bibliográficos
Autores principales: Bradner, James E., West, Nathan, Grachan, Melissa L., Greenberg, Edward F., Haggarty, Stephen J., Warnow, Tandy, Mazitschek, Ralph
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822059/
https://www.ncbi.nlm.nih.gov/pubmed/20139990
http://dx.doi.org/10.1038/nchembio.313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822059/
https://www.ncbi.nlm.nih.gov/pubmed/20139990
http://dx.doi.org/10.1038/nchembio.313

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