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Chemical Phylogenetics of Histone Deacetylases

The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of Class I and II HDACs as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even amo...

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Detalles Bibliográficos
Autores principales:	Bradner, James E., West, Nathan, Grachan, Melissa L., Greenberg, Edward F., Haggarty, Stephen J., Warnow, Tandy, Mazitschek, Ralph
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822059/ https://www.ncbi.nlm.nih.gov/pubmed/20139990 http://dx.doi.org/10.1038/nchembio.313

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