Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfolded protein response (UPR). Here we report the creation of a novel mouse model where GRP78...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Miao, Ye, Risheng, Barron, Ernesto, Baumeister, Peter, Mao, Changhui, Luo, Shengzhan, Fu, Yong, Luo, Biquan, Dubeau, Louis, Hinton, David R., Lee, Amy S.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822118/
https://www.ncbi.nlm.nih.gov/pubmed/19816510
http://dx.doi.org/10.1038/cdd.2009.144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822118/
https://www.ncbi.nlm.nih.gov/pubmed/19816510
http://dx.doi.org/10.1038/cdd.2009.144

Ejemplares similares