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Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfolded protein response (UPR). Here we report the creation of a novel mouse model where GRP78...

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Detalles Bibliográficos
Autores principales:	Wang, Miao, Ye, Risheng, Barron, Ernesto, Baumeister, Peter, Mao, Changhui, Luo, Shengzhan, Fu, Yong, Luo, Biquan, Dubeau, Louis, Hinton, David R., Lee, Amy S.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822118/ https://www.ncbi.nlm.nih.gov/pubmed/19816510 http://dx.doi.org/10.1038/cdd.2009.144

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