Differences in the transactivation domains of p53 family members: a computational study

The N terminal transactivation domain of p53 is regulated by ligases and coactivator proteins. The functional conformation of this region appears to be an alpha helix which is necessary for its appropriate interactions with several proteins including MDM2 and p300. Folding simulation studies have be...

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Detalles Bibliográficos
Autores principales: Mavinahalli, Jagadeesh N, Madhumalar, Arumugam, Beuerman, Roger W, Lane, David P, Verma, Chandra
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822533/
https://www.ncbi.nlm.nih.gov/pubmed/20158876
http://dx.doi.org/10.1186/1471-2164-11-S1-S5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822533/
https://www.ncbi.nlm.nih.gov/pubmed/20158876
http://dx.doi.org/10.1186/1471-2164-11-S1-S5

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