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Persistent Mitochondrial Damage by Nitric Oxide and its Derivatives: Neuropathological Implications
Approximately 15 years ago we reported that cytochrome c oxidase (CcO) was persistently inhibited as a consequence of endogenous induction and activation of nitric oxide ((•)NO) synthase-2 (NOS2) in astrocytes. Furthermore, the reactive nitrogen species implicated was peroxynitrite. In contrast to t...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Research Foundation
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822548/ https://www.ncbi.nlm.nih.gov/pubmed/20162100 http://dx.doi.org/10.3389/neuro.14.001.2010 |