IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection of variants with improved affinity for antigen. Long-lived memory B cells and plasma cells are also generated in GCs, although how B cell differentiation in GCs is regulated is unclear. IL-21, secreted by...

Descripción completa

Detalles Bibliográficos
Autores principales: Zotos, Dimitra, Coquet, Jonathan M., Zhang, Yang, Light, Amanda, D'Costa, Kathy, Kallies, Axel, Corcoran, Lynn M., Godfrey, Dale I., Toellner, Kai-Michael, Smyth, Mark J., Nutt, Stephen L., Tarlinton, David M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822601/
https://www.ncbi.nlm.nih.gov/pubmed/20142430
http://dx.doi.org/10.1084/jem.20091777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822601/
https://www.ncbi.nlm.nih.gov/pubmed/20142430
http://dx.doi.org/10.1084/jem.20091777

Ejemplares similares