Attracting AID to targets of somatic hypermutation

The process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes requires activation-induced cytidine deaminase (AID). Although mistargeting of AID is detrimental to genome integrity, the mechanism and the cis-elements responsible for targeting of AID are largely unknown. We show that three C...

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Detalles Bibliográficos
Autores principales: Tanaka, Atsushi, Shen, Hong Ming, Ratnam, Sarayu, Kodgire, Prashant, Storb, Ursula
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822603/
https://www.ncbi.nlm.nih.gov/pubmed/20100870
http://dx.doi.org/10.1084/jem.20090821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822603/
https://www.ncbi.nlm.nih.gov/pubmed/20100870
http://dx.doi.org/10.1084/jem.20090821

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