Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in other neoplasms. IDH1/2 mutations are heterozygous, and affect a single arginine residue. Recently, IDH1 mutations were identified in 8% of acute myelogenous leukemia (AML...

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Detalles Bibliográficos
Autores principales: Gross, Stefan, Cairns, Rob A., Minden, Mark D., Driggers, Edward M., Bittinger, Mark A., Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P., Su, Shinsan M., Dang, Lenny, Fantin, Valeria R., Mak, Tak W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822606/
https://www.ncbi.nlm.nih.gov/pubmed/20142433
http://dx.doi.org/10.1084/jem.20092506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822606/
https://www.ncbi.nlm.nih.gov/pubmed/20142433
http://dx.doi.org/10.1084/jem.20092506

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