The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity

BACKGROUND: The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g. LPC) produced by PLA2 activity can also activate TRP...

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Detalles Bibliográficos
Autores principales: Gentry, Clive, Stoakley, Natalie, Andersson, David A, Bevan, Stuart
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822744/
https://www.ncbi.nlm.nih.gov/pubmed/20092626
http://dx.doi.org/10.1186/1744-8069-6-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822744/
https://www.ncbi.nlm.nih.gov/pubmed/20092626
http://dx.doi.org/10.1186/1744-8069-6-4

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