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Statistical method on nonrandom clustering with application to somatic mutations in cancer

BACKGROUND: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a consequence of genomic instability and high levels of proliferation, many passenger mutations that do not contribute to the ca...

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Detalles Bibliográficos
Autores principales: Ye, Jingjing, Pavlicek, Adam, Lunney, Elizabeth A, Rejto, Paul A, Teng, Chi-Hse
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822753/
https://www.ncbi.nlm.nih.gov/pubmed/20053295
http://dx.doi.org/10.1186/1471-2105-11-11