Deletions of Immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia

BACKGROUND: Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a haematopoietic stem cell. The hallmark genetic abnormality of CML is a chimeric BCR/ABL1 fusion gene resulting from the Philadelphia chromosome rearrangement t(9;22)(q34;q11). Clinical and laboratory studi...

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Detalles Bibliográficos
Autores principales: Nacheva, Elisabeth P, Brazma, Diana, Virgili, Anna, Howard-Reeves, Julie, Chanalaris, Anastasios, Gancheva, Katya, Apostolova, Margarita, Valgañon, Mikel, Mazzullo, Helen, Grace, Colin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822760/
https://www.ncbi.nlm.nih.gov/pubmed/20082691
http://dx.doi.org/10.1186/1471-2164-11-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822760/
https://www.ncbi.nlm.nih.gov/pubmed/20082691
http://dx.doi.org/10.1186/1471-2164-11-41

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